trolling through the means have zero realization. >Scenario One: A variant that causes severe disease in a greater proportion of the
population than has occurred to date. For example, with similar morbidity/mortality to
other zoonotic coronaviruses such as SARS-CoV (~10% case fatality) or MERS-CoV
(~35% case fatality). This could be caused by:
1. Point mutations or recombination with other host or viral genes. This might occur through
a change in SARS-CoV-2 internal genes such as the polymerase proteins or accessory
proteins. These genes determine the outcome of infection by affecting the way the virus is
sensed by the cell, the speed at which the virus replicates and the anti-viral response of
the cell to infection. There is precedent for Coronaviruses (CoVs) to acquire additional
genes or sequences from the host, from themselves or from other viruses.2.By
recombination between two VOC or VUIs. One with high drift (change in the spike
glycoprotein) from the current spike glycoprotein gene used in the vaccine and the other
with a more efficient replication and transmission determined by internal genes, for
example, a recombination between beta and alpha or delta variants respectively.
Alternatively, recombination may occur between two different variants with two different
strategies for overcoming innate immunity, combining to give an additive or synergistic
change of phenotype resulting in higher replication of the virus – and potentially increased
morbidity and mortality.
Your move chief.