I GM for Dark Heresy. During one campaign, my players killed dozens of cultists, as well as a handful of Daemons and Chaos Marines. At one point, our resident guardsman pulled a large steel door off its hinges and beat a Daemonette into a pulp. I have no idea how any of them survived this campaign. Only the guardsman suffered life-threatening injury, and they only took small increments of sanity damage when they JUMPED AN IMPERIAL GUARD SCOUT CAR INTO THE WARP THROUGH A CHAOS PORTAL.
Personally, that group was the best DH group I've ever had. They had group dynamic, they got along, they were full of stupid crazy ideas that just seemed to succeed no matter how low their rolls had to be.