I guess. It's hard to be where I am, look back, and imagine giving up that chance forever. But even barring that whole family thing, can you imagine the loneliness? The lack of human relation? Sure there might be aliens, and some of them might even be sapient, but you'd be out there forever, knowing that you're never going to see another human being again. Never going to be able to tell someone that you feel, say, nostalgic, and have them really understand what you mean.
Never to watch Jeeves and Wooster again. Never to kiss a woman again. Never to even see a real smile again, or look into another human's eyes again.
Maybe I'm just the wrong breed of person for this kind of question, but to me this sounds like a proposition of torture. This is like being offered hell, and then I look around and see people accepting, and I have to wonder if they know something I don't.